By Michael Stanclift, ND

The rich orange color of turmeric is a signature of this powerfully healthy Indian spice. Even if you don’t dig the flavour of it in food, you might take turmeric in one of its many supplement forms for health benefits. Curcuma longa is the Latin name for turmeric and also hints at the name of the most talked about molecule in it, curcumin. Many people use “turmeric” and “curcumin” interchangeably, but surprisingly there isn’t that much curcumin in turmeric—curcumin makes up only about 3% of dried turmeric.1 But when we’re talking about the health benefits of turmeric, we’re usually really referring to its famous derivative, curcumin, which is the most studied component.

So why has this orange molecule become the darling of healthy living? Curcumin offers a host of health perks, is safe, and is well-tolerated by nearly every patient I’ve recommended it to. Many of the effects essentially boil down to curcumin’s ability to function as an antioxidant or balance the immune response to cellular injury.2 It can improve markers of oxidative stress and increase circulating antioxidants, such as superoxide dismutase, sometimes referred to as SOD.2 Curcumin can block the activation of NF-κB, which is involved in the immune response and can lead to undesirable effects.2

So how are these effects meaningful? Here are some of the research-backed ways I’ve utilized curcumin with the patients I’ve seen:

• Relieving joint discomfort2
• Improving insulin sensitivity2
• Maintaining healthy blood pressure2
• Reducing fat cell development2
• Reducing stress and fatigue3
• Having neuroprotective effects4
• Rebalancing the gut microbiome from a state of dysbiosis4
• Improving athletic performance and reducing exercise-induced muscle discomfort5

Before you get started
There are a few things you should know about curcumin before you run out and start taking it. First, curcumin isn’t very well absorbed, so it is often combined with other natural substances to help improve absorption. I have used it in formulations where it is combined with a black pepper extract (piperine), which can increase the availability about 20 times, and a fenugreek extract, which can increase the availability about 45 times.2,6
​
The second thing to know is that while curcumin has a great safety record, there have been cases of people taking a curcumin supplement experiencing liver injury.7,8,9 There’s some speculation that the effect may have come from another ingredient, not the curcumin, and many of the products involved contained piperine, the black pepper extract.7,9,10 In response to these concerns, I found a 90-day study of healthy volunteers who were investigated for signs of toxicity when the subjects were given highly bioavailable curcumin (with fenugreek extract).11 With this formulation no adverse effects were noted in the study, and liver enzymes remained within the normal range.11 There are two morals to this story: Always look for manufacturers with a solid reputation and transparent quality testing for their products, and seek the guidance of an experienced healthcare provider to ensure you’re taking the proper precautions and monitoring.

In healthy individuals, doses between 150-1,500 mg have been studied and appear to be beneficial, well-tolerated, and safe.5 The European Food Safety Authority (EFSA) is a bit more conservative and established an acceptable daily intake (ADI) of curcumin at 3 mg/kg/day.9 For readers in the United States, that translates to roughly 1.36 mg/lb/day or a dose equivalent to about 205 mg/day of curcumin per day for a 150-pound person.

Turmeric, along with its most active component curcumin, is clinically versatile and offers a wide range of health benefits. These qualities make it an attractive candidate to include in your healthy lifestyle. Ask your healthcare provider if you might benefit from turmeric or curcumin!
References:

1. Tayyem RF et al. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126-131.
2. Hewlings SJ et al. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92.
3. Pandaran Sudheeran S et al. Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber on occupational stress: a randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol. 2016;36(3):236-243.
4. Di Meo F et al. Curcumin, gut microbiota, and neuroprotection. Nutrients. 2019;11(10):2426.
5. Fernández-Lázaro D et al. Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review. Nutrients. 2020;12(2):501.
6. Kumar D et al. Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study. Journal of Functional Foods. 2016;22:578-587.
7. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Turmeric. [Updated 2021 May 11]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548561/
8. Chand S et al. A rare case of turmeric-induced hepatotoxicity. Intern Med J. 2020;50(2):258-259.
9. Menniti-Ippolito F et al. Turmeric (Curcuma longa L.) food supplements and hepatotoxicity: an integrated evaluation approach. Ann Ist Super Sanita. 2020;56(4):462-469.
10. Chand S et al. Author reply. Intern Med J. 2021;51(1):154.
11. Pancholi V et al. Safety assessment of a highly bioavailable curcumin-galactomannoside complex (CurQfen) in healthy volunteers, with a special reference to the recent hepatotoxic reports of curcumin supplements: A 90-days prospective study. Toxicol Rep. 2021;8:1255-1264.  

Inflammation plays a key role in the immune system.1 This physiological process, the inflammatory response, is the body’s way of protecting itself from infection due to bacteria, viruses, fungi, and other foreign substances.2 Inflammation plays a key role in the body’s natural healing process.1,2
While inflammation is natural—it is necessary in many cases—not all inflammatory responses are created equal.2 Sometimes the body might be inflamed when there are no foreign invaders the immune system needs to fight.2

Far too often, refined sugar is partly responsible.1 So if you have a serious sweet tooth and experience symptoms like redness, joint or muscle stiffness, fatigue, and loss of appetite, you may have fallen victim to the sugar-inflammation connection.1

How does added sugar cause inflammation?
Consistently eating high quantities of refined sugar can cause chronic, low-grade inflammation.1 This may lead to serious health issues like cardiovascular challenges, weight gain, or allergies.1,2
Specifically, added sugar promotes the following changes in the body:

• Gut lining damage: Frequently consuming added sugar may help bacteria and toxins from the gut move into the bloodstream.1 Long-term gut lining damage can increase inflammation, so this is something to be aware of.

• Weight gain and related issues: By consistently eating refined flours and sugars, you may experience weight gain and increased body fat.1 The latter is linked to insulin resistance, which makes it difficult for the body to regulate the processed sugars once they’re absorbed.1 Insulin resistance is also associated with inflammation.1

• Increased production of harmful compounds: Compounds called advanced glycation end products (AGEs) form when fat or protein blend with refined sugar in the blood.3 Excessive AGEs can contribute to inflammation.3

• Higher cholesterol: Low-density lipoprotein (LDL) cholesterol—the “bad” kind of cholesterol—may rise as your consumption of refined sugar increases.1 Data suggests high LDL cholesterol is linked to higher quantities of C-reactive protein, a marker of inflammation.1

While the government recommends that added sugar and solid fats combined account for no more than 5% to 15% of one’s total caloric intake, 13% of US adults’ total calories come from processed sugar.4 All of the above symptoms are linked to chronic, low-grade inflammation. That said, it’s worth noting that added sugar consumption alone is unlikely to cause severe inflammation; often, there are a number of factors at play.1

How can you support a healthier inflammation response?
​Lifestyle changes can address some of the symptoms mentioned above.1 Examples include: eliminating junk food from your diet, reducing your general stress levels, and so much more.1

Regardless, you will want to take stock of where you are at and make a conscious effort to improve your health.1 Read through the following list to see if there are areas where you can enhance your lifestyle:1,5

• Limit your intake of processed foods and beverages: This includes added sugar. Carefully read food labels, be mindful of what you order when you go out to eat, and exclude refined ingredients like white bread from your diet. Be sure to avoid hyper-processed, sugary ingredients like sucrose, glucose, and fructose.1 One study found that lowering fructose consumption can help treat inflammatory blood markers by almost 30%.5

• Opt for whole grains, healthy produce, and antioxidant-rich ingredients: When you shop for food, aim to focus on whole-grain carbohydrates like brown rice, barley, quinoa, and oats. These ingredients are chock-full of fiber, which may help to lower blood sugar and reduce inflammation. Similarly, healthy produce is packed with the antioxidants and vitamins you need to thrive—the same goes for fatty fish, nuts like almonds, and seeds.

• Lower your stress levels and engage in frequent exercise: Chronic stress can make you more susceptible to inflammation.1 To target your stress, aim to exercise regularly (by getting your heart rate up and also making time for resistance training), meditate, go on walks in nature, or engage in other activities that calm you—such as cooking or taking a hot bath.

Returning to the topic of sugar, there’s no need to give up the sweet stuff entirely. You might consider substituting processed sweets with naturally sweetened alternatives in order to reduce your inflammatory symptoms.1 The next section explains how natural sugars like honey and maple syrup may decrease inflammation.

Natural sugars and inflammation
Chances are you’re familiar with refined sugar and how it differs from the natural alternatives. Where refined sugar is separated from its source, reconfigured, and then added as a sweetener, natural sugar occurs—you guessed it--naturally in foods.1 This means it is sourced directly from a whole plant source.1
Whole foods like fruit and dairy products feature varying amounts of fructose and lactose—yet they’re also full of fiber, protein, and nutrients, so the body is equipped to process them efficiently.1 Natural sugar is not associated with inflammation.1 It is absorbed more slowly by the body, which helps to minimize blood sugar spikes.1

What does this mean? The verdict is that consuming natural sugar, within moderation, is just fine from a health and wellness standpoint.1 Added sugar, alternatively, should only be eaten rarely and in limited quantities.1 Please contact your doctor if your inflammatory symptoms persist even after eliminating refined sugar from your diet.

For more information on nutrition and general wellness topics, please visit the Metagenics blog.
​
References

1. Brown MJ. https://www.healthline.com/nutrition/sugar-and-inflammation. Healthline. Accessed July 18, 2019.
2. WebMD Staff. https://www.webmd.com/arthritis/about-inflammation. WebMD. Accessed July 22, 2019.
3. Uribarri J et al. J Am Diet Assoc. 2010;110(6):911–16.e12. doi:10.1016/j.jada.2010.03.018
4. Nordqvist C. https://www.medicalnewstoday.com/articles/248423.php. Medical News Today. Accessed July 22, 2019.
5. Brymora A et al. Nephrol Dial Transplant. 2012;27(2):608-612.

​Submitted by the Metagenics Marketing Team

BY RUTH KIRK-GARCIA | IMMUNE, INFLAMMATION | 0 COMMENT
Inflammation is the body’s initial response to cell damage and is designed to protect it from infection or further injury. Like day and night, the inflammatory process is a cycle defined by two halves – initiation and resolution.
The initiation phase begins with a local dispatch of immune cells at the site of damage, which sounds the alarm, igniting inflammation within the surrounding tissue. Once the threat of infection or damage is neutralized, the resolution response is activated, calming the initial phase of inflammation and facilitating cellular repair and recovery.
​
Unresolved Issues
The transition between initiation and resolution is required to complete the cycle of inflammation and to promote healing. However, for some people, this transition fails to occur, leading to a chronic, sustained inflammatory response. This keeps the body in the initiation phase where it cannot resolve inflammation; like a loud alarm system with a broken ‘deactivate’ button. The result? A state of unremitting inflammation that keeps the body in a cycle of tissue damage, preventing recovery.
However, for some people, this transition fails to occur, leading to a chronic, sustained inflammatory response. This keeps the body in the initiation phase where it cannot resolve inflammation; like a loud alarm system with a broken ‘deactivate’ button.

A Remedy for Resolution
If you or someone you know suffers from an inflammatory condition (such as arthritis), you will no doubt be aware of the frustration that comes from persistent symptoms, despite your efforts to find a solution. You may be doing all the right things, taking the right medications, taking steps to improve your diet, exercise and sleep, while proactively managing your stress. However, if the resolution of inflammation is impaired, you will continue to experience symptoms, as the inflammatory response cannot be ‘deactivated’. It’s no wonder that cutting-edge research in the field of inflammation resolution is turning heads, particularly in regards to a group of compounds called specialized pro-resolving mediators (SPMs).

Send in The SPMs
As their name suggests, SPMs trigger or ‘deactivate’ the resolution phase of inflammation in the body,[1] which are produced from omega-3 fatty acids, (EPA) and docosahexaenoic acid (DHA).[2] Like a half-time speech that inspires a triumphant victory, SPMs motivate the immune system to promote resolution. In the initiation phase, white blood cells are known as macrophages actively destroy problem microbes and clear the excess of immune cells released during inflammation. However, in the resolution phase, SPMs reprogram these macrophages, switching their game plan from offence to defense to help regenerate and repair damaged tissue.[3] This results in resolution, relief and recovery.
So why, if the body can produce SPMs, does inflammation remain unresolved? Research tells us that the body’s ability to produce SPMs is lower in conditions involving chronic inflammation,[4] meaning that in highly inflamed individuals, the ability to resolve inflammation is likely to be impaired. Some pharmacological anti-inflammatories (even some used to treat inflammation) may also prevent SPM activity,[5] as they inhibit inflammation preventing the body’s ability to activate the resolution phase.  This is why supplements providing SPMs are an exciting development for chronic inflammation sufferers; as restoring SPM levels goes beyond the effects of conventional treatments to actively promote resolution and full circle recovery.
This is why supplements providing SPMs are an exciting development for chronic inflammation sufferers; as restoring SPM levels goes beyond the effects of conventional treatments to actively promote resolution and full circle recovery
Viva la Resolution!
Heralding a new era of healing, SPMs offer a beacon of hope for those suffering from chronic inflammation, offering a new solution for achieving resolution! For more information on natural management of inflammation, read on by clicking here. However, if you are ready to experience the resolving effects of SPMs, contact a Practitioner near you today.

1] Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002 Oct 21;196(8):1025-37.
2] Hirahashi J. Omega-3 polyunsaturated fatty acids for the treatment of IgA nephropathy. J Clin Med. 2017 Jul;6(7):70. doi: 10.3390/jcm6070070.
3] Spite M, Clària J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014 Jan 7;19(1):21-36. doi: 10.1016/j.cmet.2013.10.006. 
4] Barden AE, Mas E, Croft KD, Phillips M, Mori TA. Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirin. Am J Clin Nutr. 2015 Dec;102(6):1357-64. doi: 10.3945/ajcn.115.116384.
5] Chiang N, Serhan CN. Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol Aspects Med. 2017 Dec;58:114-129. doi: 10.1016/j.mam.2017.03.005.

​Inflammation is a popular buzzword these days. But what causes it exactly? How can you know you have it, and if it’s something your body does naturally to help you heal, then what’s the big deal?

We’ve all been there: It’s late, you’re tired, and you don’t feel like turning the lights on just to cross a room…then bam! Shin finds coffee table. The resulting egg-shaped lump is formed when blood flow increases to the area, bringing with it neutrophils and macrophages as part of the immune response.
Symptoms of this acute inflammation are typical: redness, swelling, heat, and pain. The swelling that occurs as fluid collects in the area is also called “edema.” The symptoms last for a limited period of time—minutes to days—as the body heals itself.

Acute inflammation vs. chronic inflammation
When the body isn’t given enough time, or if the body is unable to resolve the immune response due to deficiency of certain nutrients, it can lead to chronic inflammation. This can also be caused by untreated infectious pathogens such as bacteria or viruses, as well as the adverse effects of long-term exposure to pollutants or chemicals, including smoking.1,2 Stress and obesity are also known factors that lead to chronic inflammation.3,4

Common symptoms of chronic inflammation include:

• Fatigue: When your immune system is in overdrive, it uses a lot of energy. It can also trigger a low-grade fever.5
• Gastrointestinal issues: Including constipation and diarrhea.6
• Unexplained pain: Most notably in the abdomen, chest, and joints.1,5
• Skin issues: Such as rashes, redness, or puffiness.7
• Weight gain: Especially in the “spare tire” region. As part of a vicious cycle, excess weight can be both a cause, and result, of inflammation.4,8
• High blood sugar: Inflammation can alter the body’s natural insulin processing, making the body less sensitive to insulin. High blood sugar levels also increase the inflammatory circulating cytokines.8
• Brain fog: An imbalance in blood sugar levels can also cause brain fog.8​

Another marker of inflammation is an elevated level of high-sensitivity C-reactive protein (hs-CRP) in the blood. C-reactive protein is produced in the liver when there is inflammation in the body. Increased CRP levels can lead to unwanted health conditions,9-11 but, while a raised hs-CRP level is a marker of inflammation in the body, by itself an hs-CRP test will not identify a complete outline of all the health risks due to the inflammation.12
What can we do?While acute inflammation is one way your body can heal itself, chronic inflammation should be avoided, as a prolonged inflammatory response can cause damage to healthy cells and tissue.
Consider adopting a few simple ways to decrease inflammation. If you have been experiencing the symptoms described herein and are concerned you may have chronic inflammation, make an appointment with your healthcare practitioner.
This content is not intended as a substitute for professional medical advice, diagnosis, or treatment. Individuals should always consult with their healthcare professional for advice on medical issues.
​
References:

1. https://www.healthline.com/health/chronic-inflammation. Accessed March 8, 2019.
2. Lee J et al. J Dent Res. 2012;91(2):142-149.
3. Liu, YZ et al. Front Hum Neurosci. 2017;11:316.
4. Ellulu MS et al. Arch Med Sci. 2017;13(4):851-863.
5. Informed Health Online. https://www.ncbi.nlm.nih.gov/books/NBK279298/. Accessed March 8, 2019.
6. Pahwa R et al. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK493173/. Accessed March 8, 2019.
7. Reich K. J Eur Acad Dermatol Venereol. 2012;26(Suppl 2):3-11.
8. Petrucci K. Mindbodygreen. https://www.mindbodygreen.com/0-24782/10-signs-you-have-chronic-inflammation.html. Accessed March 8, 2019.
9. Effoe VS et al. American Diabetes Association. http://care.diabetesjournals.org/content/38/9/1694. Accessed March 7, 2019.
10. Leuzzi G et al. European Respiratory Review. 2017;26:160070.
11. Ford ES et al. https://www.ahajournals.org/doi/10.1161/01.ATV.20.4.1052. Accessed March 7, 2019.
12. https://www.healthline.com/health/c-reactive-protein#results. Accessed March 11, 2019.

Submitted by the Metagenics Marketing Team

Specialized pro-resolving mediators (SPMs) are a way to help support the body’s natural ability to resolve physical stress.1 While the body can make SPMs naturally, supplementing with exogenous SPMs may help facilitate the body’s natural resolution process and completion of its response to physical challenges.2,3*
Metagenics, in collaboration with world-renowned leaders in the field of resolution physiology and other SPM experts, set the standard for defining SPM oils based on activity for use in nutraceutical formulas. But where do these SPMs come from?

From the first drop of marine oil through a specialized fractionation protocol and creation of the finished product, Metagenics follows a stringent, patent-pending process to create SPM Active®.

The SPM fractionation process:
SPM Active is developed through an advanced, patent-pending fractionation process which Metagenics exclusively brings to practitioners. SPM Active is a fraction produced from a high-quality marine oil. This fraction contains standardized levels of 17-HDHA and 18-HEPE, which can lead to the formation of resolvins, an important group of SPMs, in the body. The SPM Active fraction has also been shown to be bioactive and support the existing resolution mechanisms of the body.*

While SPMs are sourced from marine lipids, they are not the same as fish oil. In fact, work done during the development of SPM Active shows that fractions, from the same marine oil starting point, behave differently—not all are pro-resolving, and some fractions may have the opposite effect.4 This makes it essential to test and understand the bioactivity of SPM-rich oils.

Additionally, even though EPA and DHA are the precursors of SPMs, they do not have pro-resolving properties of SPMs.1 EPA and DHA require multiple downstream enzymatic conversions to form 17-HDHA and 18-HEPE, which are further converted into specialized pro-resolving mediators.

References

1. Serhan CN. FASEB J. 2017;31(4):1273-1288.
2. Barden AE et al. Am J Clin Nutr. 2015;102:1357-1364.
3. Titos E et al. J Immunol. 2016;197:3360-3370.
4. Adapted from WO/2013/170006.  Accessed September 10, 2018.

Submitted by the Metagenics Marketing Team

Introducing SPM Active

New & Improved

SPM Active New & Improved delivers a greater concentration and dosing size of specialized pro-resolving mediators (SPMs) compared to the previous formula

What has Changed?
Double the concentration of 18-HEPE and 17-HDPA as compared to original SPM Active.
Softgel size is now double that of the original SPM Active.

What are the benefits for your patients?
Greater concentration and dosing size facilitates patient compliance.
Supplementing with SPMs may help facilitate the body's natural resolution process 

What hasn't changed?
The price
 
Why Metagenics SPM Active?
It offers a targeted nutritional approach that is designed to boost the body’s natural capacity to respond to physical stress and promote resolution.
Study in research models suggests that a short-term, high-fat diet may negatively impact natural production of specialized pro-resolving mediators.
Clinical case study results with SPM Active show significant improvement in biomarkers of activated immune function, increased quality of life, and reduced interference of symptoms during general activity.
Specialized pro-resolving mediators may help promote resolution of physical stress after an episode of strenuous physical exertion.

Metagenics set the standard for delivering SPMs based on activity for use in nutraceutical formulas in collaboration with world-renowned SPM experts.
 

​by Whitney Crouch, RDN, CLT
What is Golden Milk?
Popularized across social media, golden milk is a cross-cultural drink originating in Asian countries and consumed for its anti-inflammatory properties and pungent flavor. Also known as “golden milk latte” or “turmeric tea”, golden milk is made with freshly grated or ground turmeric, a pinch of freshly ground pepper, honey or lemon to taste, and hot water, milk, or dairy alternative.1-2 The addition of freshly grated or ground ginger adds extra flavor and additional anti-inflammatory characteristics, with cinnamon, cardamom, cloves and nutmeg rounding out the flavor.1-2

The Golden Milk “MVP”: Turmeric
While turmeric is the star of the show with its golden color and unique flavor, golden milk is a purposefully designed elixir including ingredients that aid in the absorption and delivery of turmeric’s polyphenolic compound, curcumin, the primary curcuminoid found in turmeric. Curcumin is a poorly absorbed compound on its own, but the addition of piperine, the active ingredient in black pepper, increases the absorption by approximately 2,000%.3 Another well-designed feature of the golden milk beverage involves the use of whole fat milk or added fat (such as coconut milk or oil) to facilitate improved bioavailability of the fat-loving (lipophilic) curcuminoid phenols; leveraging a lipophilic design has been shown to allow for greater bioaccessibility of curcuminoids.4

Golden Milk and Arthritis
Arthritis is an inflammatory condition characterized by swollen, painful joints. It affects children and adults and presents in many forms – autoimmune rheumatoid arthritis, osteoarthritis, and infectious arthritis, to name a few.5-6 While each condition has a different etiology, the clinical presentation includes stiff joints, muscle aches and pains, fatigue, rigidity, and inability to use the affected limb(s).5-6
Sometimes called degenerative joint disease, osteoarthritis (OA) is the most common chronic condition of the joints, affecting approximately 27 million Americans.5 OA can affect any joint, but it occurs most often in knees, hips, lower back and neck, small joints of the fingers and the bases of the thumb and big toe.5 In OA, the cartilage breaks down, causing pain, swelling and problems moving joints.5
Rheumatoid arthritis is an autoimmune disease in which the body’s immune system – which normally protects its health by attacking foreign substances like bacteria and viruses – mistakenly attacks the joints. Since this is a systemic condition, it may also affect organ and body systems.6
Turmeric (Curcuma longa) is a rhizomatous perennial plant of the ginger family.7 Curcumin, the medicinal compound found in turmeric root, has been used for thousands of years, but has only recently been studied extensively. A curcuminoid polyphenol (also called diferuloylmethane), curcumin has been used medicinally in Asian countries for its antioxidant, anti-inflammatory, anti-microbial, anti-mutagenic, and anti-cancer properties.8

Typical anti-inflammatory medications are successful in blocking the pro-inflammatory COX pathway, while curcumin’s benefits are seen via inhibiting actions of both COX and LOX enzymes, prostaglandins, and leukotrienes.9 Unlike many non-steroidal anti-inflammatory drugs (NSAIDs), curcumin does not irritate the gastric lining when taken with food.10
Recent studies have examined the role of curcumin in the gut, specifically its interaction with the gut microbiota. Highly concentrated amounts of curcumin have been used as a standalone or adjunct approach to many clinical conditions. Until recently the dose of curcumin ingested through daily food intake and its clinical relevance was not well understood.
Oral administration of curcumin is beneficially involved in many health processes, including those underlying osteoarthritis and rheumatoid arthritis.11 Limited bioavailability and inability to detect curcumin in circulation or target tissues has hindered the validation of a causal role, however studies suggest the relationship between curcumin, microbiota, and gut tissue to be at the base of improved overall health and reduced inflammation with dietary intake of turmeric.12
In their review of current studies, Gosh, et al. theorize that the mechanism underlying the attenuation of metabolic dysfunction is a curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into blood circulation, by maintaining the integrity of the intestinal barrier function.12 In this role, lacking extensive systemic circulation, curcumin reduces the release inflammatory LPS molecules, thereby protecting several layers of the intestinal barrier.12
While the data on curcumin’s role in supporting healthy joints and combating arthritis is growing, it should be noted that the clinically effective doses studied range from 1000-1500 mg/day of curcuminoids. The typical golden milk recipe includes 0.5-3 teaspoons of turmeric, or approximately 3-9 grams of ground turmeric root.1-2,14 With the lower bioavailability of dietary curcumin, and the curcumin content of the turmeric root averaging 3.14% by weight,13 actual curcuminoid intake per golden milk drink ranges from 0.05-0.28 mg when preparing it with 0.5-3 teaspoons of turmeric (based on simple math).
Golden milk tea is a wellness-promoting drink that should be incorporated into a nutrient dense, anti-inflammatory diet and lifestyle. While higher, more targeted doses of curcumin may be necessary to promote clinically significant changes in arthritic pain outcomes, the sum of all diet and lifestyle parts should be considered when approaching inflammation from a more natural, holistic perspective.

References: 

1. The New York Times. Rao T. Turmeric Tea. https://cooking.nytimes.com/recipes/1018548-turmeric-tea. Accessed June 7, 2018.
2. Andrew Weil, MD. Anti-Inflammatory Golden Milk Tea. https://www.drweil.com/diet-nutrition/anti-inflammatory-diet-pyramid/anti-inflammatory-golden-milk/. Accessed June 7, 2018.
3. Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med.1998;64(4):353–356.
4. Fu S et al. Enhanced bioaccessibility of curcuminoids in buttermilk yogurt in comparison to curcuminoids in aqueous dispersions. J Food Sci. 2016;81(3):H769-776.
5. Arthritis Foundation. What is Osteoarthritis? https://www.arthritis.org/about-arthritis/types/osteoarthritis/what-is-osteoarthritis.php. Accessed May 30, 2018.
6. Arthritis Foundation. Rheumatoid Arthritis. www.arthritis.org/about-arthritis/types/rheumatoid-arthritis/. Accessed May 30, 2018.
7. Priyadarsini KI. The chemistry of curcumin: from extraction to therapeutic agent. Molecules.2014;19(12):20091–20112.
8. Aggarwal BB et al. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res.2003;23(1A):363–398.
9. Perkins K et al. Efficacy of curcuma for treatment of osteoarthritis. J Evid Based Complementary Altern Med. 2017;22(2):156–165.
10. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Review.2009;14(2):141-153.
11. Belcaro G et al. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55–62.
12. Ghosh SS et al. Curcumin-mediated regulation of intestinal barrier function the mechanism underlying its beneficial effects. Tissue Barriers. 2018;6(1):e1425085.
13. Tayyem RF et al. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126–131. 
14. USDA National Nutrient Database for Standard Reference. 02043, Spices, turmeric, ground.Accessed June 7, 2018.

Whitney Crouch, RDN, CLT
Whitney Crouch is a Registered Dietitian with a BS in Clinical Nutrition from the University of California, Davis. She has over 10 years of experience across multiple areas of dietetics, specializing in integrative and functional nutrition and food sensitivities. When she’s not writing about nutrition or educating others, she’s spending time with her husband and young son. She’s often found running around the bay near her home with the family’s dog or in the kitchen cooking up new ideas to help her picky eater expand his palate.

Golden Fusion is a modern take on the centuries-old golden milk recipe that is both great-tasting and convenient. Golden Fusion features CurQFen - a highly bioavailable form of curcumin with fenugreek, along with grass-fed collagen peptides.

What is Golden Milk?
Popularized across social media, golden milk is a cross-cultural drink originating in Asian countries and consumed for its anti-inflammatory properties and pungent flavour. Also known as “golden milk latte” or “turmeric tea”, golden milk is made with freshly grated or ground turmeric, a pinch of freshly ground pepper, honey or lemon to taste, and hot water, milk, or dairy alternative. The addition of freshly grated or ground ginger adds extra flavour and additional anti-inflammatory characteristics, with cinnamon, cardamom, cloves and nutmeg rounding out the flavour.

Why Golden Fusion?

• More than just turmeric and collagen, Golden Fusion is formulated using high-quality, targeted ingredients.
• Features CurQfen, a unique, patented, stable curcuminoid (from turmeric) and galactomannan (from fenugreek) compound designed for increased bioavailability
• Curcumin, a major curcuminoid found in turmeric, may beneficially modulate signalling molecules that influence immune function
• Offers VERISOL® Bioactive Collagen Peptides® that help support skin and nail health
• Combines turmeric with collagen peptides for an innovative twist on traditional golden milk

The Golden Milk: Turmeric
While turmeric is the star of the show with its golden colour and unique flavour, golden milk is a purposefully designed elixir including ingredients that aid in the absorption and delivery of turmeric’s polyphenolic compound, curcumin, the primary curcuminoid found in turmeric. Curcumin is a poorly absorbed compound on its own, but the addition of piperine, the active ingredient in black pepper, increases the absorption by approximately 2,000%. Another well-designed feature of the golden milk beverage involves the use of whole fat milk or added fat (such as coconut milk or oil) to facilitate improved bioavailability of the fat-loving (lipophilic) curcuminoid phenols; leveraging a lipophilic design has been shown to allow for greater bio-accessibility of curcuminoids.
How To Enjoy Golden Fusion:
Mix one scoop with 150ml of hot water or your favourite milk (cow's, coconut, or almond) for a great-tasting and comforting way to supplement your diet with curcumin and collagen peptides.
 
Frequently Asked Questions...
 
What’s the Ancient Secret of Golden Milk?
With roots in traditional Chinese and Indian recipes, golden milk dates back thousands of years, and is used within the ancient branch of Indian medicine known as Ayurveda as a nourishing, delicious tonic that supports the mind and body in several ways.
The main ingredient in golden milk is turmeric, which gives it a beautiful yellow colour and healing benefits. Traditionally used to impart colour and flavour to Indian curries, the health benefits of turmeric are well-documented and researched. These include anti-inflammatory properties and support of detoxification, as well as the potential to improve cognitive function, blood sugar balance, joint health, and more.

What is the source is of our golden fusion collagen?
The source is grass-fed bovine collagen.

What is the type of collagen used?

• Primarily type I and type III.
• The collagen is hydrolyzed (pre-digested, resulting in bioactive collagen peptides)

Why does Metagenics list “Predominantly Grass-Fed” Collagen Peptides?
Grass-Fed designation is often desirable because some experts believe that these cows may deliver greater nutritional benefits. However, labeling grass-fed without qualifying with “predominantly” would be is false and misleading. The majority of cows are not exclusively grass-fed because they often eat other food, such as grain, when weather is bad and there is no grass to eat. Many other companies and suppliers do not disclose this information.
We pride ourselves on quality and transparency and will continue to set the standard for clear and accurate labelling.

What’s Eating You?
Feeling overly tired, bloated, or achy? When dealing with these often stress-related concerns, there are a few questions you should ask yourself: Am I eating well? Am I getting enough sleep? Do I drink enough water and get enough exercise?
A healthy body handles daily stress better while an unhealthy lifestyle and daily stress can contribute to a deeper issue—chronic inflammation.
Inflammation is the body’s natural response to fighting off potential health threats, but unhealthy lifestyle choices can stunt the resolution of your immune response. In fact, chronic low-grade inflammation is often related to common chronic illnesses. But here’s the good news: There are a few ways you can help resolve your body’s inflammation response—starting today!

1. Ditch That Diet
Unfortunately, many of us do not receive our fair share of nutrients from food. You may feel tired and overworked, and rather than taking the time to prepare a healthy, well-balanced meal, you may often resort to convenient inflammatory trigger foods that are lacking in nutrients: refined starches, high-fat and processed red meats, fried foods, dairy, etc. These may cause an activation of the innate immune system and lead to excessive production of pro-inflammatory cytokines.
It’s time to break the cycle by incorporating anti-inflammatory foods into your day. A Mediterranean-style diet, for example, typically has a high ratio of monounsaturated fatty acids as compared to saturated fats, and more omega-3 to omega-6 polyunsaturated fatty acids. It’s also rich in fresh fruits, vegetables, legumes, and whole grains, which have shown anti-inflammatory effects in observational and intervention studies.

2. Stay Hydrated
This one is obvious. It’s always important to drink enough water throughout the day and ensure you are properly hydrated. Water makes up a large percentage of our bodies to keep all our physiological systems working together smoothly, and it helps flush out toxins and unwanted chemicals we may pick up from the environment.
Tip: Bored with plain water? Add in fresh fruit slices to liven up your H2O. Antioxidant-packed green tea is also great for afternoon sipping.
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3. Put Stress to Rest
In our fast-paced modern culture, you may find yourself working too much and not getting enough rest. The initial stress response can be positive, but when left unchecked, it can lead to chronic stress and become pro-inflammatory. This is when getting extra sleep, practising yoga, or taking on leisurely activities you love can make a world of difference.
Catching those Zs at night is especially important because it’s your body’s time to rest and recharge. Lack of sleep can make you feel sluggish, unmotivated, and irritable, which only compounds a  stress problem; and increased stress disturbs the quality of your sleep. Research has also linked higher levels of inflammatory proteins to getting fewer hours of sleep at night.
In addition to getting proper rest, taking time to move and exercising are helpful stress relievers, as they release “feel-good” endorphins and can reduce your body’s levels of adrenaline and cortisol (stress hormones).
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It’s never too late to make positive life changes!Eating a nutrient-rich diet, ensuring proper hydration, and taking time for relaxation, exercise, and healthy sleep habits are some simple ways you can support your body’s best health today.