Specialized pro-resolving mediators (SPMs) are a way to help support the body’s natural ability to resolve physical stress.1 While the body can make SPMs naturally, supplementing with exogenous SPMs may help facilitate the body’s natural resolution process and completion of its response to physical challenges.2,3*
Metagenics, in collaboration with world-renowned leaders in the field of resolution physiology and other SPM experts, set the standard for defining SPM oils based on activity for use in nutraceutical formulas. But where do these SPMs come from?
From the first drop of marine oil through a specialized fractionation protocol and creation of the finished product, Metagenics follows a stringent, patent-pending process to create SPM Active®.
The SPM fractionation process:
SPM Active is developed through an advanced, patent-pending fractionation process which Metagenics exclusively brings to practitioners. SPM Active is a fraction produced from a high-quality marine oil. This fraction contains standardized levels of 17-HDHA and 18-HEPE, which can lead to the formation of resolvins, an important group of SPMs, in the body. The SPM Active fraction has also been shown to be bioactive and support the existing resolution mechanisms of the body.*
While SPMs are sourced from marine lipids, they are not the same as fish oil. In fact, work done during the development of SPM Active shows that fractions, from the same marine oil starting point, behave differently—not all are pro-resolving, and some fractions may have the opposite effect.4 This makes it essential to test and understand the bioactivity of SPM-rich oils.
Additionally, even though EPA and DHA are the precursors of SPMs, they do not have pro-resolving properties of SPMs.1 EPA and DHA require multiple downstream enzymatic conversions to form 17-HDHA and 18-HEPE, which are further converted into specialized pro-resolving mediators.
Introducing SPM Active
New & Improved
SPM Active New & Improved delivers a greater concentration and dosing size of specialized pro-resolving mediators (SPMs) compared to the previous formula
What has Changed?
Double the concentration of 18-HEPE and 17-HDPA as compared to original SPM Active.
Softgel size is now double that of the original SPM Active.
What are the benefits for your patients?
Greater concentration and dosing size facilitates patient compliance.
Supplementing with SPMs may help facilitate the body's natural resolution process
What hasn't changed?
Why Metagenics SPM Active?
It offers a targeted nutritional approach that is designed to boost the body’s natural capacity to respond to physical stress and promote resolution.
Study in research models suggests that a short-term, high-fat diet may negatively impact natural production of specialized pro-resolving mediators.
Clinical case study results with SPM Active show signiﬁcant improvement in biomarkers of activated immune function, increased quality of life, and reduced interference of symptoms during general activity.
Specialized pro-resolving mediators may help promote resolution of physical stress after an episode of strenuous physical exertion.
Metagenics set the standard for delivering SPMs based on activity for use in nutraceutical formulas in collaboration with world-renowned SPM experts.
When you first decide to supplement with fish oils to support your overall health, you may wonder: With so many product options available, how do I know what to look for?
Watch for Purity Testing when selecting a fish oil supplement, know there are various forms of testing that can be done to ensure the source meets quality standards. You should feel confident that the fish oil you choose lives up to its purity and potency claims and has been extensively tested for contaminants that are potentially harmful. Here’s what you need to know.
Something’s Fishy - Don’t settle for a lesser fish oil. Seek out a reputable supplement company that conducts potency testing in addition to testing for the following contaminants and toxins.
If you suspect a bad fish oil, remember: There are plenty of other fish in the sea!
Fishing for Good Health
Experience the benefits of fish oil by choosing a quality formula with proof of testing to meet your standards and support overall health.*
What’s Eating You?
Feeling overly tired, bloated, or achy? When dealing with these often stress-related concerns, there are a few questions you should ask yourself: Am I eating well? Am I getting enough sleep? Do I drink enough water and get enough exercise?
A healthy body handles daily stress better while an unhealthy lifestyle and daily stress can contribute to a deeper issue—chronic inflammation.
Inflammation is the body’s natural response to fighting off potential health threats, but unhealthy lifestyle choices can stunt the resolution of your immune response. In fact, chronic low-grade inflammation is often related to common chronic illnesses. But here’s the good news: There are a few ways you can help resolve your body’s inflammation response—starting today!
1. Ditch That Diet
Unfortunately, many of us do not receive our fair share of nutrients from food. You may feel tired and overworked, and rather than taking the time to prepare a healthy, well-balanced meal, you may often resort to convenient inflammatory trigger foods that are lacking in nutrients: refined starches, high-fat and processed red meats, fried foods, dairy, etc. These may cause an activation of the innate immune system and lead to excessive production of pro-inflammatory cytokines.
It’s time to break the cycle by incorporating anti-inflammatory foods into your day. A Mediterranean-style diet, for example, typically has a high ratio of monounsaturated fatty acids as compared to saturated fats, and more omega-3 to omega-6 polyunsaturated fatty acids. It’s also rich in fresh fruits, vegetables, legumes, and whole grains, which have shown anti-inflammatory effects in observational and intervention studies.
2. Stay Hydrated
This one is obvious. It’s always important to drink enough water throughout the day and ensure you are properly hydrated. Water makes up a large percentage of our bodies to keep all our physiological systems working together smoothly, and it helps flush out toxins and unwanted chemicals we may pick up from the environment.
Tip: Bored with plain water? Add in fresh fruit slices to liven up your H2O. Antioxidant-packed green tea is also great for afternoon sipping.
3. Put Stress to Rest
In our fast-paced modern culture, you may find yourself working too much and not getting enough rest. The initial stress response can be positive, but when left unchecked, it can lead to chronic stress and become pro-inflammatory. This is when getting extra sleep, practising yoga, or taking on leisurely activities you love can make a world of difference.
Catching those Zs at night is especially important because it’s your body’s time to rest and recharge. Lack of sleep can make you feel sluggish, unmotivated, and irritable, which only compounds a stress problem; and increased stress disturbs the quality of your sleep. Research has also linked higher levels of inflammatory proteins to getting fewer hours of sleep at night.
In addition to getting proper rest, taking time to move and exercising are helpful stress relievers, as they release “feel-good” endorphins and can reduce your body’s levels of adrenaline and cortisol (stress hormones).
It’s never too late to make positive life changes!Eating a nutrient-rich diet, ensuring proper hydration, and taking time for relaxation, exercise, and healthy sleep habits are some simple ways you can support your body’s best health today.